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Crystal structure of plasmodium falciparum lactate dehydrogenase mutant W107FA.

Analyse Crystal structure of plasmodium falciparum lactate dehydrogenase mutant W107FA. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4PLZ
Type: protein
Length: 302 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: L-lactate dehydrogenase
EC: 1.1.1.27
UniProt: Q71T02
Ligands: OXM, NAI
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	L-lactate dehydrogenase (EC 1.1.1.27)	protein	302	50% helix, 21% strand	Q71T02

Ligands and binding sites

OXM · Oxamic acid · ligand · chains A
NAI · 1,4-dihydronicotinamide adenine dinucleotide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	415	0.61	0.76	56	OXM, NAI
2	125	0.44	0.77	22	empty

Compared structures

4PLZ · Crystal structure of Plasmodium falciparum lactate dehydrogenase mutant W107fA. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q71T02
Elsewhere: RCSB PDB 4PLZ · PDBe 4PLZ · UniProt Q71T02

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