MolNFT v1 · #103578 · protein

The structure of a conserved piezo channel domain reveals a novel beta sandwich fold

4PKX · Protein C10C5.1, isoform I: “The structure of a conserved piezo channel domain reveals a novel beta sandwich fold”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #103578 on GenesisL1: 3D structure, binding sites…

PDB: 4PKX
Type: protein
Length: 235 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein C10C5.1, isoform I
UniProt: O01260
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein C10C5.1, isoform I	protein	235	24% helix, 34% strand	O01260

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	83	0.45	0.81	21	empty
2	104	0.37	0.75	21	empty

Compared structures

4PKX · The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O01260
Elsewhere: RCSB PDB 4PKX · PDBe 4PKX · UniProt O01260

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