MolNFT v1 · #103561 · protein
The structure of a conserved piezo channel domain reveals a novel beta sandwich fold
4PKE · Protein C10C5.1, isoform I: “The structure of a conserved piezo channel domain reveals a novel beta sandwich fold”. X-ray diffraction, 1 ligand (PT), 3 pockets (best druggability 0.49). MolNFT v1 #103561 on GenesisL1: 3D structure…
- PDB
- 4PKE
- Type
- protein
- Length
- 211 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein C10C5.1, isoform I
- UniProt
- O01260
- Ligands
- PT
- Pockets
- 3 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein C10C5.1, isoform I | protein | 211 | 20% helix, 33% strand | O01260 |
Ligands and binding sites
- PT · Platinum (II) ion · metal · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.49 | 0.82 | 23 | empty |
| 2 | 65 | 0.42 | 0.81 | 26 | empty |
| 3 | 72 | 0.41 | 0.79 | 16 | empty |
Compared structures
- 4PKE · The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O01260
- Elsewhere: RCSB PDB 4PKE · PDBe 4PKE · UniProt O01260
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