MolNFT v1 · #103400 · protein

Myosin VI motor domain in the pi release state, space group P212121

4PFO · Unconventional myosin-VI: “Myosin VI motor domain in the pi release state, space group P212121”. X-ray diffraction, 2 ligands (ADP, MG), 6 pockets (best druggability 0.85). MolNFT v1 #103400 on GenesisL1: 3D structure, binding sites…

PDB: 4PFO
Type: protein
Length: 755 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Unconventional myosin-VI
UniProt: F1RQI7
Ligands: ADP, MG
Pockets: 6 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Unconventional myosin-VI	protein	755	48% helix, 16% strand	F1RQI7

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A
GOL · Glycerol · additive · 14 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	984	0.85	0.86	120	MG, ADP, GOL
2	423	0.69	0.81	46	GOL
3	94	0.61	0.88	21	GOL
4	98	0.47	0.80	16	empty
5	58	0.35	0.78	20	GOL

Compared structures

4PFO · Myosin VI motor domain in the Pi release state, space group P212121 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F1RQI7
Elsewhere: RCSB PDB 4PFO · PDBe 4PFO · UniProt F1RQI7

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