Research workbench

Myosin VI motor domain in the pi release state, space group P212121

Analyse Myosin VI motor domain in the pi release state, space group P212121 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4PFO
Type: protein
Length: 755 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Unconventional myosin-VI
UniProt: F1RQI7
Ligands: ADP, MG
Pockets: 6 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Unconventional myosin-VI	protein	755	48% helix, 16% strand	F1RQI7

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A
GOL · Glycerol · additive · 14 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	984	0.85	0.86	120	MG, ADP, GOL
2	423	0.69	0.81	46	GOL
3	94	0.61	0.88	21	GOL
4	98	0.47	0.80	16	empty
5	58	0.35	0.78	20	GOL

Compared structures

4PFO · Myosin VI motor domain in the Pi release state, space group P212121 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F1RQI7
Elsewhere: RCSB PDB 4PFO · PDBe 4PFO · UniProt F1RQI7

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