MolNFT v1 · #103141 · protein
Structure of human beta-cardiac myosin motor DOMAIN::GFP chimera
4P7H · Myosin-7,GREEN fluorescent protein: “Structure of human beta-cardiac myosin motor DOMAIN::GFP chimera”. X-ray diffraction, 2 ligands (CRO, SO4), 20 pockets (best druggability 0.84). MolNFT v1 #103141 on GenesisL1: 3D structure…
- PDB
- 4P7H
- Type
- protein
- Length
- 1,923 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-7,GREEN fluorescent protein
- UniProt
- P12883, P42212
- Ligands
- CRO, SO4
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-7,GREEN fluorescent protein | protein | 971 | 37% helix, 22% strand | P12883, P42212 |
| B | Myosin-7,GREEN fluorescent protein | protein | 952 | 37% helix, 24% strand | P12883, P42212 |
Ligands and binding sites
- CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1106 | 0.84 | 0.85 | 129 | empty |
| 2 | 1081 | 0.81 | 0.82 | 72 | empty |
| 3 | 107 | 0.77 | 0.97 | 29 | CRO |
| 4 | 102 | 0.77 | 0.97 | 24 | CRO |
| 5 | 816 | 0.75 | 0.79 | 75 | SO4 |
Interfaces
1 interface between chains.
- A–B · 1437 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 cofactor (chromophore).
Compared structures
- 4P7H · Structure of Human beta-Cardiac Myosin Motor Domain::GFP chimera · the same entry in another collection · chain A against A, TM-score 1.00
- P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain B against A, TM-score 0.69
- P42212 · AlphaFold monomer V2.0 prediction for green fluorescent protein (P42212) · a predicted model of the same protein · chain B against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12883
- Every structure of UniProt P42212
- Elsewhere: RCSB PDB 4P7H · PDBe 4P7H · UniProt P12883 · UniProt P42212
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