MolNFT v1 · #103093 · protein
Structure of the N-terminal domain of the human mitochondrial ASPARTATE/GLUTAMATE carrier aralar in the calcium-bound state
4P5X · Calcium-binding mitochondrial carrier protein ARALAR1: “Structure of the N-terminal domain of the human mitochondrial ASPARTATE/GLUTAMATE carrier aralar in the…”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.58).…
- PDB
- 4P5X
- Type
- protein
- Length
- 267 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium-binding mitochondrial carrier protein ARALAR1
- UniProt
- O75746
- Ligands
- CA
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 60% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium-binding mitochondrial carrier protein ARALAR1 | protein | 267 | 60% helix, 6% strand | O75746 |
Ligands and binding sites
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 373 | 0.58 | 0.75 | 42 | empty |
| 2 | 66 | 0.35 | 0.77 | 19 | empty |
Compared structures
- 4P5X · Structure of the N-terminal domain of the human mitochondrial aspartate/glutamate carrier… · the same entry in another collection · chain A against A, TM-score 1.00
- O75746 · AlphaFold monomer V2.0 prediction for calcium-binding mitochondrial carrier protein… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75746
- Elsewhere: RCSB PDB 4P5X · PDBe 4P5X · UniProt O75746
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