MolNFT v1 · #102983 · protein
Quiescin sulfhydryl oxidase from rattus norvegicus
4P2L · Sulfhydryl oxidase 1: “Quiescin sulfhydryl oxidase from rattus norvegicus”. X-ray diffraction, 1 ligand (FAD), 13 pockets (best druggability 0.87). MolNFT v1 #102983 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4P2L
- Type
- protein
- Length
- 991 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sulfhydryl oxidase 1
- EC
- 1.8.3.2
- UniProt
- Q6IUU3
- Ligands
- FAD
- Pockets
- 13 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sulfhydryl oxidase 1 (EC 1.8.3.2) | protein | 498 | 45% helix, 12% strand | Q6IUU3 |
| B | Sulfhydryl oxidase 1 (EC 1.8.3.2) | protein | 493 | 45% helix, 13% strand | Q6IUU3 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 691 | 0.87 | 0.91 | 79 | FAD |
| 2 | 668 | 0.87 | 0.91 | 79 | FAD |
| 3 | 204 | 0.51 | 0.76 | 35 | empty |
| 4 | 169 | 0.51 | 0.78 | 25 | empty |
| 5 | 229 | 0.51 | 0.76 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 1234 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6IUU3
- Elsewhere: RCSB PDB 4P2L · PDBe 4P2L · UniProt Q6IUU3
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