MolNFT v1 · #102866 · protein
Crystal structure of human caperalpha U2AF homology motif (apo-state)
4OZ0 · RNA-binding protein 39: “Crystal structure of human caperalpha U2AF homology motif (apo-state)”. X-ray diffraction, 1 ligand (CL), 2 pockets (best druggability 0.30). MolNFT v1 #102866 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4OZ0
- Type
- protein
- Length
- 221 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-binding protein 39
- UniProt
- Q14498
- Ligands
- CL
- Pockets
- 2 · best druggability 0.30
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-binding protein 39 | protein | 113 | 30% helix, 19% strand | Q14498 |
| B | RNA-binding protein 39 | protein | 108 | 34% helix, 20% strand | Q14498 |
Ligands and binding sites
- CL · Chloride ion · ion · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.30 | 0.76 | 13 | empty |
| 2 | 52 | 0.27 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 431 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 4OZ0 · Crystal structure of human CAPERalpha U2AF homology motif (apo-state) · the same entry in another collection · chain A against A, TM-score 1.00
- Q14498 · AlphaFold monomer V2.0 prediction for RNA-binding protein 39 (Q14498) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14498
- Elsewhere: RCSB PDB 4OZ0 · PDBe 4OZ0 · UniProt Q14498
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