MolNFT v1 · #10275 · protein

Crystal structure of unligated HPPK(R82A) from E.COLI at 1.74 ångström resolution

1IM6 · 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: “Crystal structure of unligated HPPK(R82A) from E.COLI at 1.74 ångström resolution”. X-ray diffraction, 1 ligand (CL), 2 pockets (best druggability 0.37). MolNFT v1 #10275 on…

PDB: 1IM6
Type: protein
Length: 158 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
EC: 2.7.6.3
UniProt: P26281
Ligands: CL
Pockets: 2 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (EC 2.7.6.3)	protein	158	30% helix, 27% strand	P26281

Ligands and binding sites

CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.37	0.80	13	empty
2	54	0.29	0.75	12	empty

Compared structures

1IM6 · Crystal structure of unligated HPPK(R82A) from E.COLI at 1.74 ångström resolution · the same entry in another collection · chain A against A, TM-score 1.00
P26281 · AlphaFold monomer V2.0 prediction for 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine… · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26281
Elsewhere: RCSB PDB 1IM6 · PDBe 1IM6 · UniProt P26281

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.