MolNFT v1 · #102699 · protein

Crystal structure of the C-terminal domain from yeast GCN2

4OTM · SERINE/THREONINE-protein kinase GCN2: “Crystal structure of the C-terminal domain from yeast GCN2”. X-ray diffraction, 1 pocket (best druggability 0.48). MolNFT v1 #102699 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4OTM
Type: protein
Length: 232 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase GCN2
EC: 2.7.11.1
UniProt: P15442
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase GCN2 (EC 2.7.11.1)	protein	114	48% helix, 17% strand	P15442
B	SERINE/THREONINE-protein kinase GCN2 (EC 2.7.11.1)	protein	118	45% helix, 16% strand	P15442

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.48	0.85	24	empty

Interfaces

1 interface between chains.

A–B · 2230 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

4OTM · Crystal structure of the C-terminal domain from yeast GCN2 · the same entry in another collection · chain A against A, TM-score 1.00
P15442 · AlphaFold monomer V2.0 prediction for eif-2-alpha kinase GCN2 (P15442) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15442
Elsewhere: RCSB PDB 4OTM · PDBe 4OTM · UniProt P15442

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