MolNFT v1 · #102674 · protein
Structure of uncleaved glycine-bound human L-asparaginase protein
4OSX · Isoaspartyl PEPTIDASE/L-asparaginase: “Structure of uncleaved glycine-bound human L-asparaginase protein”. X-ray diffraction, 2 ligands (GLY, NA), 3 pockets (best druggability 0.57). MolNFT v1 #102674 on GenesisL1: 3D structure…
- PDB
- 4OSX
- Type
- protein
- Length
- 600 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoaspartyl PEPTIDASE/L-asparaginase
- EC
- 3.4.19.5, 3.5.1.1
- UniProt
- Q7L266
- Ligands
- GLY, NA
- Pockets
- 3 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Isoaspartyl PEPTIDASE/L-asparaginase (EC 3.4.19.5, 3.5.1.1) | protein | 300 | 33% helix, 27% strand | Q7L266 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 197 | 0.57 | 0.80 | 41 | GLY |
| 2 | 153 | 0.51 | 0.79 | 31 | GLY |
| 3 | 95 | 0.38 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1896 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 4OSX · STRUCTURE of UNCLEAVED GLYCINE-BOUND HUMAN L-ASPARAGINASE PROTEIN · the same entry in another collection · chain A against A, TM-score 1.00
- Q7L266 · AlphaFold monomer V2.0 prediction for isoaspartyl PEPTIDASE/L-asparaginase (Q7L266) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7L266
- Elsewhere: RCSB PDB 4OSX · PDBe 4OSX · UniProt Q7L266
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