MolNFT v1 · #102349 · protein

The structure of aquaporin

4OJ2 · Aquaporin-2: “The structure of aquaporin”. X-ray diffraction, 2 pockets (best druggability 0.56). MolNFT v1 #102349 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4OJ2
Type: protein
Length: 253 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aquaporin-2
UniProt: P41181
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Aquaporin-2	protein	253	69% helix, 0% strand	P41181

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	114	0.56	0.83	30	empty
2	91	0.41	0.78	19	empty

Compared structures

4OJ2 · The structure of aquaporin · the same entry in another collection · chain X against X, TM-score 1.00
P41181 · AlphaFold monomer V2.0 prediction for aquaporin-2 (P41181) · a predicted model of the same protein · chain X against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41181
Elsewhere: RCSB PDB 4OJ2 · PDBe 4OJ2 · UniProt P41181

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