UniProt P41181
Aquaporin-2 (P41181)
Aquaporin-2 (UniProt P41181): 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P41181
- Protein
- Aquaporin-2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 23 · 2 records with a druggable one
Structures
9 records of P41181 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NEF | X-ray structure of human Aquaporin 2 | x-ray diffraction | A, B, C, D | — | — |
| 4NEF | X-ray structure of human aquaporin 2 | x-ray diffraction | A, B, C, D | — | — |
| 4OJ2 | The structure of aquaporin | x-ray diffraction | X | — | — |
| 4OJ2 | The structure of aquaporin | x-ray diffraction | X | — | — |
| 6QF5 | X-Ray structure of human Aquaporin 2 crystallized on a silicon chip | x-ray diffraction | A, B, C, D | CD | 11 (best 0.68) |
| 6QF5 | X-ray structure of human aquaporin 2 crystallized on a silicon chip | x-ray diffraction | A, B, C, D | CD | — |
| 8GCL | Cryo-EM structure of hAQP2 in DDM | electron microscopy | A | — | 2 (best 0.47) |
| 8GHJ | Crystal structure of human AQP2 T125M mutant | x-ray diffraction | A, B, C, D | CD | 10 (best 0.63) |
| P41181 | AlphaFold monomer V2.0 prediction for aquaporin-2 (P41181) | predicted | A | — | — |
Ligands
- CD · Cadmium ion · in 3 records
Experiment against prediction
- 8GCL chain A against the predicted model P41181: TM-score 1.00, RMSD 0.35 Å
- 6QF5 chain D against the predicted model P41181: TM-score 0.98, RMSD 0.87 Å
- 6QF5 chain D against the predicted model P41181: TM-score 0.98, RMSD 0.87 Å
- 8GHJ chain B against the predicted model P41181: TM-score 0.98, RMSD 1.07 Å
- 6QF5 chain C against the predicted model P41181: TM-score 0.97, RMSD 1.14 Å
- 6QF5 chain C against the predicted model P41181: TM-score 0.97, RMSD 1.14 Å
- 8GHJ chain D against the predicted model P41181: TM-score 0.95, RMSD 1.49 Å
- 4NEF chain D against the predicted model P41181: TM-score 0.95, RMSD 1.42 Å
- 4NEF chain D against the predicted model P41181: TM-score 0.95, RMSD 1.42 Å
- 4NEF chain B against the predicted model P41181: TM-score 0.95, RMSD 1.17 Å
Elsewhere
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