MolNFT v1 · #102291 · protein

Leopard syndrome-associated SHP2/G464A mutant

4OHE · Tyrosine-protein phosphatase non-receptor type 11: “Leopard syndrome-associated SHP2/G464A mutant”. X-ray diffraction, 5 pockets (best druggability 0.64). MolNFT v1 #102291 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4OHE
Type: protein
Length: 489 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 11
EC: 3.1.3.48
UniProt: Q06124
Pockets: 5 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	489	31% helix, 25% strand	Q06124

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	444	0.64	0.78	45	empty
2	90	0.50	0.82	18	empty
3	66	0.42	0.81	15	empty
4	100	0.41	0.77	23	empty
5	63	0.28	0.73	13	empty

Compared structures

4OHE · LEOPARD Syndrome-Associated SHP2/G464A mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06124
Elsewhere: RCSB PDB 4OHE · PDBe 4OHE · UniProt Q06124

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