MolNFT v1 · #102100 · protein

Crystal structure of arabidopsis thaliana cytosolic triose phosphate isomerase

4OBT · Triosephosphate isomerase, cytosolic: “Crystal structure of arabidopsis thaliana cytosolic triose phosphate isomerase”. X-ray diffraction, 3 pockets (best druggability 0.42). MolNFT v1 #102100 on GenesisL1: 3D structure, binding…

PDB: 4OBT
Type: protein
Length: 500 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Triosephosphate isomerase, cytosolic
EC: 5.3.1.1
UniProt: P48491
Pockets: 3 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Triosephosphate isomerase, cytosolic (EC 5.3.1.1)	protein	250	45% helix, 16% strand	P48491

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.42	0.80	22	empty
2	108	0.42	0.77	26	empty
3	113	0.41	0.76	27	empty

Interfaces

1 interface between chains.

A–B · 1494 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

4OBT · Crystal structure of Arabidopsis thaliana cytosolic triose phosphate isomerase · the same entry in another collection · chain A against A, TM-score 1.00
P48491 · AlphaFold monomer V2.0 prediction for triosephosphate isomerase, cytosolic (P48491) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48491
Elsewhere: RCSB PDB 4OBT · PDBe 4OBT · UniProt P48491

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