MolNFT v1 · #101980 · protein
Crystal structure of human ALKBH5 in complex with MN2+
4O7X · RNA demethylase ALKBH5: “Crystal structure of human ALKBH5 in complex with MN2+”. X-ray diffraction, 1 ligand (MN), 1 pocket (best druggability 0.60). MolNFT v1 #101980 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4O7X
- Type
- protein
- Length
- 210 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA demethylase ALKBH5
- EC
- 1.14.11.-
- UniProt
- Q6P6C2
- Ligands
- MN
- Pockets
- 1 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA demethylase ALKBH5 (EC 1.14.11.-) | protein | 210 | 28% helix, 30% strand | Q6P6C2 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.60 | 0.83 | 36 | MN |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P6C2
- Elsewhere: RCSB PDB 4O7X · PDBe 4O7X · UniProt Q6P6C2
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