MolNFT v1 · #10154 · protein
Crystal structure of the mitotic kinesin EG5 in complex with mg-ADP.
1II6 · Kinesin-related motor protein EG5: “Crystal structure of the mitotic kinesin EG5 in complex with mg-ADP.”. X-ray diffraction, 3 ligands (ADP, MG, NO3), 5 pockets (best druggability 0.80). MolNFT v1 #10154 on GenesisL1: 3D structure…
- PDB
- 1II6
- Type
- protein
- Length
- 675 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin-related motor protein EG5
- UniProt
- P52732
- Ligands
- ADP, MG, NO3
- Pockets
- 5 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin-related motor protein EG5 | protein | 340 | 34% helix, 27% strand | P52732 |
| B | Kinesin-related motor protein EG5 | protein | 335 | 32% helix, 29% strand | P52732 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
- NO3 · Nitrate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1142 | 0.80 | 0.82 | 120 | MG, ADP |
| 2 | 64 | 0.56 | 0.89 | 19 | empty |
| 3 | 218 | 0.54 | 0.78 | 31 | empty |
| 4 | 202 | 0.54 | 0.78 | 33 | empty |
| 5 | 150 | 0.51 | 0.79 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1044 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 1II6 · Crystal Structure of the Mitotic Kinesin Eg5 in Complex with Mg-ADP. · the same entry in another collection · chain A against A, TM-score 1.00
- P52732 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF11 (P52732) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52732
- Elsewhere: RCSB PDB 1II6 · PDBe 1II6 · UniProt P52732
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.