MolNFT v1 · #101502 · protein

Crystal structure of glit

4NTC: “Crystal structure of glit”. X-ray diffraction, 1 ligand (FAD), 6 pockets (best druggability 0.82). MolNFT v1 #101502 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4NTC
Type: protein
Length: 639 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glit
UniProt: Q5MBU7
Ligands: FAD
Pockets: 6 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glit	protein	325	27% helix, 29% strand	Q5MBU7
B	Glit	protein	314	29% helix, 29% strand	Q5MBU7

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	829	0.82	0.85	92	FAD
2	767	0.82	0.85	87	FAD
3	62	0.72	0.97	16	empty
4	179	0.51	0.77	31	empty
5	144	0.40	0.74	22	empty

Interfaces

1 interface between chains.

A–B · 2466 Å² buried · 39 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4NTC · Crystal structure of GliT · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5MBU7
Elsewhere: RCSB PDB 4NTC · PDBe 4NTC · UniProt Q5MBU7

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