MolNFT v1 · #101454 · protein
Crystal structure of human ALKBH5 in complex with pyridine-2,4- dicarboxylate
4NRQ · RNA demethylase ALKBH5: “Crystal structure of human ALKBH5 in complex with pyridine-2,4- dicarboxylate”. X-ray diffraction, 2 ligands (PD2, MN), 1 pocket (best druggability 0.67). MolNFT v1 #101454 on GenesisL1: 3D structure…
- PDB
- 4NRQ
- Type
- protein
- Length
- 210 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA demethylase ALKBH5
- EC
- 1.14.11.-
- UniProt
- Q6P6C2
- Ligands
- PD2, MN
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA demethylase ALKBH5 (EC 1.14.11.-) | protein | 210 | 28% helix, 29% strand | Q6P6C2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.67 | 0.89 | 29 | PD2, MN |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4NRQ · Crystal structure of human ALKBH5 in complex with pyridine-2,4-dicarboxylate · the same entry in another collection · chain A against A, TM-score 1.00
- Q6P6C2 · AlphaFold monomer V2.0 prediction for RNA demethylase ALKBH5 (Q6P6C2) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P6C2
- Elsewhere: RCSB PDB 4NRQ · PDBe 4NRQ · UniProt Q6P6C2
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