MolNFT v1 · #101446 · protein
Crystal structure of a human MMS2/UBC13 A122G mutant
4NRI · Ubiquitin-conjugating enzyme E2 variant 2: “Crystal structure of a human MMS2/UBC13 A122G mutant”. X-ray diffraction, 1 pocket (best druggability 0.44). MolNFT v1 #101446 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4NRI
- Type
- protein
- Length
- 285 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2 variant 2; Ubiquitin-conjugating enzyme E2 N
- EC
- 6.3.2.19
- UniProt
- Q15819, P61088
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-conjugating enzyme E2 variant 2 | protein | 140 | 23% helix, 20% strand | Q15819 |
| B | Ubiquitin-conjugating enzyme E2 N (EC 6.3.2.19) | protein | 145 | 35% helix, 21% strand | P61088 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.44 | 0.76 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 798 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4NRI · Crystal Structure of a human Mms2/Ubc13 A122G mutant · the same entry in another collection · chain A against A, TM-score 1.00
- Q15819 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 variant 2 (Q15819) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P61088 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 N (P61088) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15819
- Every structure of UniProt P61088
- Elsewhere: RCSB PDB 4NRI · PDBe 4NRI · UniProt Q15819 · UniProt P61088
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.