Crystal structure of the bromodomain of human BAZ2B in complex with compound-3 N01186

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 0% strand (DSSP).

Ligands and binding sites

• 2LY · N-methyl-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide · ligand · chains A
• EDO · 1,2-ethanediol · additive · 2 copies · chains A
• 15P · Polyethylene glycol (N=34) · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 4NRC · Crystal Structure of the bromodomain of human BAZ2B in complex with compound-3 N01186 · the same entry in another collection · chain A against A, TM-score 1.00
• Q9UIF8 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9UIF8
• Elsewhere: RCSB PDB 4NRC · PDBe 4NRC · UniProt Q9UIF8