MolNFT v1 · #101358 · protein

Crystal structure of GDP-bound A143S mutant of the S. thermophilus feob G-domain

4NON · Ferrous iron uptake transporter protein B: “Crystal structure of GDP-bound A143S mutant of the S. thermophilus feob G-domain”. X-ray diffraction, 1 ligand (GDP), 5 pockets (best druggability 0.78). MolNFT v1 #101358 on GenesisL1: 3D…

PDB: 4NON
Type: protein
Length: 518 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ferrous iron uptake transporter protein B
UniProt: Q5M586
Ligands: GDP
Pockets: 5 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ferrous iron uptake transporter protein B	protein	260	48% helix, 18% strand	Q5M586
B	Ferrous iron uptake transporter protein B	protein	258	49% helix, 17% strand	Q5M586

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	648	0.78	0.83	73	empty
2	161	0.64	0.85	31	empty
3	55	0.54	0.89	18	empty
4	58	0.36	0.79	16	empty
5	50	0.33	0.77	13	empty

Interfaces

1 interface between chains.

A–B · 1095 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

4NON · Crystal structure of GDP-bound A143S mutant of the S. thermophilus FeoB G-domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5M586
Elsewhere: RCSB PDB 4NON · PDBe 4NON · UniProt Q5M586

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