Crystal structure of galectin-1 L11A mutant

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 61% strand (DSSP).

Ligands and binding sites

• BGC · beta-D-glucopyranose · sugar · 6 copies · chains A, B, C, D, E, F
• GAL · beta-D-galactopyranose · sugar · 6 copies · chains A, B, C, D, E, F
• MG · Magnesium ion · metal · 3 copies · chains A, B, C, F
• SO4 · Sulfate ion · ion · 2 copies · chains A, E
• GOL · Glycerol · additive · 6 copies · chains A, F, B, C, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

7 interfaces between chains.

• A–C · 944 Ų buried · 24 hydrogen bonds · protein-protein
• D–E · 923 Ų buried · 21 hydrogen bonds · protein-protein
• A–F · 343 Ų buried · 7 hydrogen bonds · protein-protein
• A–E · 227 Ų buried · 6 hydrogen bonds · protein-protein
• A–B · 193 Ų buried · 2 hydrogen bonds · protein-protein

Compared structures

• 4NO4 · Crystal Structure of Galectin-1 L11A mutant · the same entry in another collection · chain C against C, TM-score 1.00
• P11762 · AlphaFold monomer V2.0 prediction for galectin-1 (P11762) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P11762
• Elsewhere: RCSB PDB 4NO4 · PDBe 4NO4 · UniProt P11762