MolNFT v1 · #101182 · protein
Crystal structure of pyrococcus furiosus L-asparaginase with ligand
4NJE: “Crystal structure of pyrococcus furiosus L-asparaginase with ligand”. X-ray diffraction, 1 ligand (ASP), 1 pocket (best druggability 0.40). MolNFT v1 #101182 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4NJE
- Type
- protein
- Length
- 309 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-asparaginase
- EC
- 3.5.1.1
- UniProt
- Q8TZE8
- Ligands
- ASP
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-asparaginase (EC 3.5.1.1) | protein | 182 | 30% helix, 31% strand | Q8TZE8 |
| B | L-asparaginase (EC 3.5.1.1) | protein | 127 | 35% helix, 14% strand | Q8TZE8 |
Ligands and binding sites
- ASP · Aspartic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.40 | 0.76 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 938 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TZE8
- Elsewhere: RCSB PDB 4NJE · PDBe 4NJE · UniProt Q8TZE8
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