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MolNFT v1 · #101106 · protein + RNA

Structure of human dicer platform-paz-connector helix cassette in complex with 14-mer siRNA having 5'-puu and uu-3' ends (2.55 ångström resolution)

4NH5 · Endoribonuclease dicer: “Structure of human dicer platform-paz-connector helix cassette in complex with 14-mer siRNA having 5'-puu and…”. X-ray diffraction, 2 pockets (best druggability 0.69). MolNFT v1 #101106 on GenesisL1: 3D…

PDB
4NH5
Type
protein + RNA
Length
285 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Endoribonuclease dicer; 5'-R(P*UP*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3'
EC
3.1.26.-
UniProt
Q9UPY3
Pockets
2 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 27% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AEndoribonuclease dicer (EC 3.1.26.-)protein27128% helix, 27% strandQ9UPY3
B5'-R(P*UP*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3'rna14——

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
13980.690.8158empty
21280.470.7823empty

Interfaces

1 interface between chains.

  • A–B · 497 Ų buried · 15 hydrogen bonds · protein-nucleic

Compared structures

  • 4NH5 · Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 14-mer… · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9UPY3 · AlphaFold monomer V2.0 prediction for endoribonuclease dicer (Q9UPY3) · a predicted model of the same protein · chain A against A, TM-score 0.93

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