UniProt Q9UPY3
Endoribonuclease Dicer (Q9UPY3)
Endoribonuclease Dicer (UniProt Q9UPY3), EC 3.1.26.3: 30 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 96 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UPY3
- Protein
- Endoribonuclease Dicer
- EC
- 3.1.26.3
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 96 · 5 records with a druggable one
Structures
31 records of Q9UPY3 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EB1 | Crystal Structure of the C-Terminal RNase III Domain of Human Dicer | x-ray diffraction | A, B, C | — | — |
| 2EB1 | Crystal structure of the C-terminal RNase III domain of human dicer | x-ray diffraction | A, B, C | — | — |
| 4NGB | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NGB | Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NGC | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NGC | Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NGD | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NGD | Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NGF | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 17-mer siRNA having… | x-ray diffraction | A, B, C, D | — | — |
| 4NGF | Structure of human dicer platform-paz-connector helix cassette in complex with 17-mer siRNA having… | x-ray diffraction | A, B, C, D | — | — |
| 4NGG | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 13-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NGG | Structure of human dicer platform-paz-connector helix cassette in complex with 13-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NH3 | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 13-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NH3 | Structure of human dicer platform-paz-connector helix cassette in complex with 13-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NH5 | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 14-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NH5 | Structure of human dicer platform-paz-connector helix cassette in complex with 14-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NH6 | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 15-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NH6 | Structure of human dicer platform-paz-connector helix cassette in complex with 15-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NHA | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 16-mer siRNA having… | x-ray diffraction | A | — | — |
| 4NHA | Structure of human dicer platform-paz-connector helix cassette in complex with 16-mer siRNA having… | x-ray diffraction | A | — | — |
| 4WYQ | Crystal structure of the Dicer-TRBP interface | x-ray diffraction | A, D | — | — |
| 4WYQ | Crystal structure of the dicer-trbp interface | x-ray diffraction | A, D | — | — |
| 5ZAK | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | electron microscopy | A | — | 20 (best 0.80) |
| 5ZAK | Cryo-EM structure of human dicer and its complexes with a pre-miRNA substrate | electron microscopy | A | — | — |
| 5ZAL | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | electron microscopy | A | — | 20 (best 0.82) |
| 5ZAL | Cryo-EM structure of human dicer and its complexes with a pre-miRNA substrate | electron microscopy | A | — | — |
| 5ZAM | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | electron microscopy | A | — | 20 (best 0.85) |
| 5ZAM | Cryo-EM structure of human dicer and its complexes with a pre-miRNA substrate | electron microscopy | A | — | — |
| 7XW2 | Cryo-EM structure of human DICER-pre-miRNA in a dicing state | electron microscopy | A | CA | 16 (best 0.82) |
| 7XW3 | Cryo-EM structure of an apo-form of human DICER | electron microscopy | A | — | 20 (best 0.82) |
| Q9UPY3 | AlphaFold monomer V2.0 prediction for endoribonuclease dicer (Q9UPY3) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 1 record
Experiment against prediction
- 2EB1 chain C against the predicted model Q9UPY3: TM-score 0.98, RMSD 0.66 Å
- 2EB1 chain C against the predicted model Q9UPY3: TM-score 0.98, RMSD 0.66 Å
- 2EB1 chain B against the predicted model Q9UPY3: TM-score 0.98, RMSD 0.69 Å
- 2EB1 chain B against the predicted model Q9UPY3: TM-score 0.98, RMSD 0.69 Å
- 2EB1 chain A against the predicted model Q9UPY3: TM-score 0.98, RMSD 0.79 Å
- 2EB1 chain A against the predicted model Q9UPY3: TM-score 0.98, RMSD 0.79 Å
- 4NHA chain A against the predicted model Q9UPY3: TM-score 0.96, RMSD 1.32 Å
- 4NHA chain A against the predicted model Q9UPY3: TM-score 0.96, RMSD 1.32 Å
- 4NH5 chain A against the predicted model Q9UPY3: TM-score 0.93, RMSD 1.53 Å
- 4NH5 chain A against the predicted model Q9UPY3: TM-score 0.93, RMSD 1.53 Å
Elsewhere
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