MolNFT v1 · #101065 · protein
Crystal structure of polymerase subunit pa N-terminal endonuclease domain from bat-derived influenza virus H17N10
4NFZ · Polymerase pa: “Crystal structure of polymerase subunit pa N-terminal endonuclease domain from bat-derived influenza virus…”. X-ray diffraction, 1 ligand (MN), 5 pockets (best druggability 0.78). MolNFT v1 #101065 on GenesisL1: 3D…
- PDB
- 4NFZ
- Type
- protein
- Length
- 588 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase pa
- UniProt
- H6QM92
- Ligands
- MN
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Polymerase pa | protein | 196 | 44% helix, 16% strand | H6QM92 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 529 | 0.78 | 0.85 | 61 | empty |
| 2 | 703 | 0.77 | 0.82 | 79 | MN |
| 3 | 399 | 0.65 | 0.79 | 44 | MN |
| 4 | 211 | 0.47 | 0.74 | 32 | empty |
| 5 | 51 | 0.26 | 0.73 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–C · 582 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 508 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 446 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4NFZ · Crystal structure of polymerase subunit PA N-terminal endonuclease domain from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H6QM92
- Elsewhere: RCSB PDB 4NFZ · PDBe 4NFZ · UniProt H6QM92
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