MolNFT v1 · #10105 · protein
Type 1 insulin-like growth factor receptor (domains 1-3)
1IGR · Insulin-like growth factor receptor 1: “Type 1 insulin-like growth factor receptor (domains 1-3)”. X-ray diffraction, 5 ligands (NAG, FUC, BMA), 5 pockets (best druggability 0.51). MolNFT v1 #10105 on GenesisL1: 3D structure…
- PDB
- 1IGR
- Type
- protein
- Length
- 471 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor receptor 1
- EC
- 2.7.10.1
- UniProt
- P08069
- Ligands
- NAG, FUC, BMA, MAN, SO4
- Pockets
- 5 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor receptor 1 (EC 2.7.10.1) | protein | 471 | 11% helix, 27% strand | P08069 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A
- FUC · alpha-L-fucopyranose · sugar · 2 copies · chains A
- BMA · beta-D-mannopyranose · sugar
- MAN · alpha-D-mannopyranose · sugar
- SO4 · Sulfate ion · ion · 8 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.51 | 0.79 | 21 | SO4 |
| 2 | 72 | 0.38 | 0.78 | 18 | empty |
| 3 | 87 | 0.34 | 0.74 | 15 | empty |
| 4 | 54 | 0.29 | 0.75 | 14 | empty |
| 5 | 54 | 0.26 | 0.73 | 19 | empty |
Modifications
Observed in the structure: 15 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 1IGR · Type 1 Insulin-like growth factor receptor (DOMAINS 1-3) · the same entry in another collection · chain A against A, TM-score 1.00
- P08069 · AlphaFold monomer V2.0 prediction for insulin-like growth factor 1 receptor (P08069) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08069
- Elsewhere: RCSB PDB 1IGR · PDBe 1IGR · UniProt P08069
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