MolNFT v1 · #100488 · protein

Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain, C131W mutant

4MZ3 · Sodium channel subunit beta-4: “Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain, C131W mutant”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #100488 on GenesisL1: 3D…

PDB: 4MZ3
Type: protein
Length: 240 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sodium channel subunit beta-4
UniProt: Q8IWT1
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Sodium channel subunit beta-4	protein	120	3% helix, 49% strand	Q8IWT1

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.55	0.81	28	empty
2	73	0.36	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 928 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (artifact).

Compared structures

4MZ3 · Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular… · the same entry in another collection · chain A against A, TM-score 1.00
Q8IWT1 · AlphaFold monomer V2.0 prediction for sodium channel subunit beta-4 (Q8IWT1) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IWT1
Elsewhere: RCSB PDB 4MZ3 · PDBe 4MZ3 · UniProt Q8IWT1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.