MolNFT v1 · #100078 · protein
Crystal structure of prefusion-stabilized rsv F variant CAV1 at pH 5.5
4MMS · Fusion glycoprotein F2: “Crystal structure of prefusion-stabilized rsv F variant CAV1 at pH 5.5”. X-ray diffraction, 1 ligand (SO4), 17 pockets (best druggability 0.86). MolNFT v1 #100078 on GenesisL1: 3D structure, binding sites…
- PDB
- 4MMS
- Type
- protein
- Length
- 1,348 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F2; Fusion glycoprotein F1 fused with fibritin trimerization domain
- UniProt
- P03420, P10104
- Ligands
- SO4
- Pockets
- 17 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 31% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Fusion glycoprotein F2 | protein | 81 | 31% helix, 33% strand | P03420 |
| B, D | Fusion glycoprotein F1 fused with fibritin trimerization domain | protein | 370 | 31% helix, 32% strand | P03420, P10104 |
| C | Fusion glycoprotein F2 | protein | 77 | 32% helix, 36% strand | P03420 |
| F | Fusion glycoprotein F1 fused with fibritin trimerization domain | protein | 369 | 30% helix, 33% strand | P03420, P10104 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 14 copies · chains B, E, F, A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 991 | 0.86 | 0.87 | 80 | empty |
| 2 | 423 | 0.79 | 0.88 | 51 | empty |
| 3 | 810 | 0.77 | 0.80 | 71 | SO4 |
| 4 | 145 | 0.74 | 0.93 | 27 | empty |
| 5 | 436 | 0.70 | 0.81 | 50 | empty |
Interfaces
9 interfaces between chains.
- A–B · 4411 Ų buried · 79 hydrogen bonds · protein-protein
- E–F · 4393 Ų buried · 86 hydrogen bonds · protein-protein
- C–D · 4314 Ų buried · 82 hydrogen bonds · protein-protein
- B–D · 1796 Ų buried · 17 hydrogen bonds · protein-protein
- D–F · 1723 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 21 disulfide (disulfide).
Compared structures
- 4MMS · Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 5.5 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03420
- Every structure of UniProt P10104
- Elsewhere: RCSB PDB 4MMS · PDBe 4MMS · UniProt P03420 · UniProt P10104
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.