MolNFT v1 · #499159 · protein
AlphaFold monomer V2.0 prediction for tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (P57081)
P57081: “AlphaFold monomer V2.0 prediction for tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4…”. 3 pockets (best druggability 0.80). MolNFT v1 #499159 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P57081
- Type
- protein
- Length
- 412 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB44F19a0cb161828322eEEd13F55d4C3C34938d2
- Molecule
- TRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
- UniProt
- P57081
- Pockets
- 3 · best druggability 0.80
Structure
1 distinct chain · 11% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 | protein | 412 | 11% helix, 43% strand | P57081 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 729 | 0.80 | 0.84 | 47 | empty |
| 2 | 98 | 0.62 | 0.89 | 24 | empty |
| 3 | 159 | 0.46 | 0.76 | 24 | empty |
Compared structures
- 8EG0 · CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA and SAH · an experimental structure of the same protein · chain A against B, TM-score 0.83
- 8D58 · Crystal structure of human METTL1-WDR4 complex · an experimental structure of the same protein · chain A against B, TM-score 0.80
- 8D9K · CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA · an experimental structure of the same protein · chain A against B, TM-score 0.79
- 7U20 · Crystal structure of human METTL1 and WDR4 complex · an experimental structure of the same protein · chain A against B, TM-score 0.78
- 8H0N · Crystal structure of the human METTL1-WDR4 complex · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 8CTH · Cryo-EM structure of human METTL1-WDR4-tRNA(Phe) complex · an experimental structure of the same protein · chain A against B, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P57081
- Elsewhere: UniProt P57081 · AlphaFold DB P57081
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