UniProt P57081
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (P57081)
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (UniProt P57081): 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 47 pockets. Binding sites, druggability and experiment against…
- UniProt
- P57081
- Protein
- tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 47 · 9 records with a druggable one
Structures
9 records of P57081 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7U20 | Crystal structure of human METTL1 and WDR4 complex | x-ray diffraction | B | SO4 | 5 (best 0.81) |
| 8CTH | Cryo-EM structure of human METTL1-WDR4-tRNA(Phe) complex | electron microscopy | B | — | 4 (best 0.78) |
| 8CTI | Cryo-EM structure of human METTL1-WDR4-tRNA(Val) complex | electron microscopy | B | — | 4 (best 0.80) |
| 8D58 | Crystal structure of human METTL1-WDR4 complex | x-ray diffraction | B | CL | 4 (best 0.80) |
| 8D9K | CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA | electron microscopy | B | — | 6 (best 0.82) |
| 8D9L | CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA and SAM | electron microscopy | B | — | 7 (best 0.81) |
| 8EG0 | CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA and SAH | electron microscopy | B | — | 10 (best 0.84) |
| 8H0N | Crystal structure of the human METTL1-WDR4 complex | x-ray diffraction | A | — | 4 (best 0.79) |
| P57081 | AlphaFold monomer V2.0 prediction for tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit… | predicted | A | — | 3 (best 0.80) |
Ligands
Experiment against prediction
- 8CTI chain B against the predicted model P57081: TM-score 0.98, RMSD 0.89 Å
- 8D9K chain B against the predicted model P57081: TM-score 0.98, RMSD 0.96 Å
- 8H0N chain A against the predicted model P57081: TM-score 0.98, RMSD 0.97 Å
- 8CTH chain B against the predicted model P57081: TM-score 0.98, RMSD 0.98 Å
- 8D9L chain B against the predicted model P57081: TM-score 0.98, RMSD 1.09 Å
- 8EG0 chain B against the predicted model P57081: TM-score 0.97, RMSD 1.33 Å
- 7U20 chain B against the predicted model P57081: TM-score 0.96, RMSD 1.61 Å
- 8D58 chain B against the predicted model P57081: TM-score 0.95, RMSD 1.31 Å
Elsewhere
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