MolNFT v1 · #498040 · protein
AlphaFold monomer V2.0 prediction for vacuolar protein sorting- associated protein 4B (O75351)
O75351 · Vacuolar protein sorting-associated protein 4B: “AlphaFold monomer V2.0 prediction for vacuolar protein sorting- associated protein 4B (O75351)”. 2 pockets (best druggability 0.53). MolNFT v1 #498040 on GenesisL1: 3D structure…
- Accession
- O75351
- Type
- protein
- Length
- 444 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xFfdda12F81300c334dA5663cd65680B4a9a77303
- Molecule
- Vacuolar protein sorting-associated protein 4B
- UniProt
- O75351
- Pockets
- 2 · best druggability 0.53
Structure
1 distinct chain · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vacuolar protein sorting-associated protein 4B | protein | 444 | 52% helix, 13% strand | O75351 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.53 | 0.83 | 19 | empty |
| 2 | 92 | 0.46 | 0.80 | 21 | empty |
Compared structures
- 1XWI · Crystal Structure of VPS4B · an experimental structure of the same protein · chain A against A, TM-score 0.69
- 1XWI · Crystal structure of VPS4B · an experimental structure of the same protein · chain A against A, TM-score 0.69
- 7L9X · Structure of VPS4B in complex with an allele-specific covalent inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 7L9X · Structure of VPS4B in complex with an allele-specific covalent inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 2CPT · Solution structure of mit domain from human SKD1 · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 2CPT · Solution structure of MIT domain from human SKD1 · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 4U7Y · Structure of the complex of VPS4B MIT and IST1 MIM · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 4U7Y · Structure of the complex of VPS4B mit and IST1 mim · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 1WR0 · Structural characterization of the mit domain from human VPS4B · an experimental structure of the same protein · chain A against A, TM-score 0.17
- 1WR0 · Structural characterization of the MIT domain from human Vps4b · an experimental structure of the same protein · chain A against A, TM-score 0.17
- 2JQK · VPS4B MIT-CHMP2B Complex · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 2JQK · VPS4B mit-CHMP2B complex · an experimental structure of the same protein · chain A against A, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75351
- Elsewhere: UniProt O75351 · AlphaFold DB O75351
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