MolNFT v1 · #494731 · protein
AlphaFold monomer V2.0 prediction for vacuolating cytotoxin autotransporter (Q48245)
Q48245: “AlphaFold monomer V2.0 prediction for vacuolating cytotoxin autotransporter (Q48245)”. 7 pockets (best druggability 0.82). MolNFT v1 #494731 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q48245
- Type
- protein
- Length
- 1,287 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7782F4817b37743d738e9aF842bf74bd50f2015E
- Molecule
- Vacuolating cytotoxin autotransporter
- UniProt
- Q48245
- Pockets
- 7 · best druggability 0.82
Structure
1 distinct chain · 13% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vacuolating cytotoxin autotransporter | protein | 1287 | 13% helix, 45% strand | Q48245 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 612 | 0.82 | 0.88 | 89 | empty |
| 2 | 532 | 0.67 | 0.77 | 48 | empty |
| 3 | 447 | 0.66 | 0.78 | 33 | empty |
| 4 | 147 | 0.49 | 0.78 | 26 | empty |
| 5 | 84 | 0.44 | 0.80 | 17 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6NYJ · Helicobacter pylori vacuolating cytotoxin a oligomeric assembly 2B (oa-2B) · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6NYF · Helicobacter pylori vacuolating cytotoxin a oligomeric assembly 1 (oa- 1) · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6NYN · Helicobacter pylori vacuolating cytotoxin a oligomeric assembly 2E (oa-2E) · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6NYL · Helicobacter pylori vacuolating cytotoxin a oligomeric assembly 2C (oa-2C) · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6NYM · Helicobacter pylori Vacuolating Cytotoxin A Oligomeric Assembly 2d (OA-2d) · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6NYM · Helicobacter pylori vacuolating cytotoxin a oligomeric assembly 2D (oa-2D) · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6NYG · Helicobacter pylori vacuolating cytotoxin a oligomeric assembly 2A (oa-2A) · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 6ODY · Cryo-EM structure of helicobacter pylori vaca hexamer · an experimental structure of the same protein · chain A against A, TM-score 0.52
- 2QV3 · Crystal structure of the helicobacter pylori vacuolating toxin P55 domain · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 2QV3 · Crystal Structure of the Helicobacter pylori Vacuolating Toxin p55 Domain · an experimental structure of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q48245
- Elsewhere: UniProt Q48245 · AlphaFold DB Q48245
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