MolNFT v1 · #482101 · protein
AlphaFold monomer V2.0 prediction for general transcriptional corepressor TUP1 (P16649)
P16649: “AlphaFold monomer V2.0 prediction for general transcriptional corepressor TUP1 (P16649)”. 3 pockets (best druggability 0.81). MolNFT v1 #482101 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P16649
- Type
- protein
- Length
- 713 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xA5c98ce6810a16B92Cbab4B878Cb05BeDef05E8E
- Molecule
- General transcriptional corepressor TUP1
- UniProt
- P16649
- Pockets
- 3 · best druggability 0.81
Structure
1 distinct chain · 19% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | General transcriptional corepressor TUP1 | protein | 713 | 19% helix, 25% strand | P16649 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 572 | 0.81 | 0.87 | 53 | empty |
| 2 | 134 | 0.41 | 0.75 | 24 | empty |
| 3 | 55 | 0.32 | 0.77 | 19 | empty |
Compared structures
- 1ERJ · Crystal structure of the C-terminal WD40 domain of TUP1 · an experimental structure of the same protein · chain A against C, TM-score 0.50
- 1ERJ · Crystal structure of the C-terminal WD40 domain of TUP1 · an experimental structure of the same protein · chain A against C, TM-score 0.50
- 3VP8 · Crystal structure of the N-terminal domain of the yeast general corepressor Tup1p · an experimental structure of the same protein · chain A against B, TM-score 0.11
- 3VP8 · Crystal structure of the N-terminal domain of the yeast general corepressor TUP1P · an experimental structure of the same protein · chain A against B, TM-score 0.11
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16649
- Elsewhere: UniProt P16649 · AlphaFold DB P16649
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