MolNFT v1 · #473172 · protein
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase TRIM33 (Q9UPN9)
Q9UPN9: “AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase TRIM33 (Q9UPN9)”. 6 pockets (best druggability 0.53). MolNFT v1 #473172 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9UPN9
- Type
- protein
- Length
- 1,127 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9e5E98E011361C5888c92e2CDb7652E02Bd5C7Ed
- Molecule
- E3 ubiquitin-protein ligase TRIM33
- UniProt
- Q9UPN9
- Pockets
- 6 · best druggability 0.53
Structure
1 distinct chain · 24% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase TRIM33 | protein | 1127 | 24% helix, 5% strand | Q9UPN9 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.53 | 0.81 | 28 | empty |
| 2 | 220 | 0.48 | 0.74 | 22 | empty |
| 3 | 88 | 0.46 | 0.80 | 17 | empty |
| 4 | 68 | 0.41 | 0.80 | 12 | empty |
| 5 | 96 | 0.39 | 0.76 | 19 | empty |
Compared structures
- 3U5O · Crystal structure of the complex of TRIM33 phd-bromo and H3(1-22) K9ME3K14ACK18AC histone… · an experimental structure of the same protein · chain A against C, TM-score 0.17
- 3U5O · Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-22)K9me3K14acK18ac histone… · an experimental structure of the same protein · chain A against C, TM-score 0.17
- 3U5N · Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-20)K9me3K14ac histone… · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 3U5N · Crystal structure of the complex of TRIM33 phd-bromo and H3(1-20) K9ME3K14AC histone… · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 3U5P · Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-28)K9me3K14acK18acK23ac… · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 3U5P · Crystal structure of the complex of TRIM33 phd-bromo and H3(1-28) K9ME3K14ACK18ACK23AC… · an experimental structure of the same protein · chain A against A, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UPN9
- Elsewhere: UniProt Q9UPN9 · AlphaFold DB Q9UPN9
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