MolNFT v1 · #473139 · protein
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase midline-1 (O15344)
O15344: “AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase midline-1 (O15344)”. 3 pockets (best druggability 0.40). MolNFT v1 #473139 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O15344
- Type
- protein
- Length
- 667 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xd1A2963012bEcbC7A8f505464439Ab678C48936f
- Molecule
- E3 ubiquitin-protein ligase midline-1
- UniProt
- O15344
- Pockets
- 3 · best druggability 0.40
Structure
1 distinct chain · 33% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase midline-1 | protein | 667 | 33% helix, 25% strand | O15344 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 120 | 0.40 | 0.75 | 21 | empty |
| 2 | 52 | 0.32 | 0.77 | 16 | empty |
| 3 | 69 | 0.29 | 0.73 | 18 | empty |
Compared structures
- 7QRY · Crystal structure of B30.2 pryspry domain of MID1 · an experimental structure of the same protein · chain A against B, TM-score 0.25
- 7QRY · Crystal structure of B30.2 PRYSPRY domain of MID1 · an experimental structure of the same protein · chain A against B, TM-score 0.25
- 2JUN · Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular… · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 2JUN · Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular… · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 2FFW · Solution structure of the RBCC/TRIM B-box1 domain of human MID1: B-box with a RING · an experimental structure of the same protein · chain A against A, TM-score 0.07
- 2FFW · Solution structure of the RBCC/TRIM B-BOX1 domain of human MID1: B-box with a ring · an experimental structure of the same protein · chain A against A, TM-score 0.07
- 2DQ5 · Solution structure of the MID1 B BOX2 CHC(D/C)C2H2 zinc-binding domain: insights into an… · an experimental structure of the same protein · chain A against A, TM-score 0.07
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15344
- Elsewhere: UniProt O15344 · AlphaFold DB O15344
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