UniProt O15344
E3 ubiquitin-protein ligase Midline-1 (O15344)
E3 ubiquitin-protein ligase Midline-1 (UniProt O15344), EC 2.3.2.27: 10 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15344
- Protein
- E3 ubiquitin-protein ligase Midline-1
- EC
- 2.3.2.27
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 10 · 1 record with a druggable one
Structures
11 records of O15344 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DQ5 | solution structure of the Mid1 B Box2 Chc(D/C)C2H2 Zinc-Binding Domain: insights into an… | solution nmr | A | — | — |
| 2DQ5 | Solution structure of the MID1 B BOX2 CHC(D/C)C2H2 zinc-binding domain: insights into an… | solution nmr | A | — | — |
| 2FFW | Solution structure of the RBCC/TRIM B-box1 domain of human MID1: B-box with a RING | solution nmr | A | — | — |
| 2FFW | Solution structure of the RBCC/TRIM B-BOX1 domain of human MID1: B-box with a ring | solution nmr | A | — | — |
| 2JUN | Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING… | solution nmr | A | — | — |
| 2JUN | Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular ring… | solution nmr | A | — | — |
| 5IM8 | Solution Structure of the Microtubule-Targeting COS Domain of MID1 | solution nmr | A | — | — |
| 5IM8 | Solution structure of the microtubule-targeting cos domain of MID1 | solution nmr | A | — | — |
| 7QRY | Crystal structure of B30.2 PRYSPRY domain of MID1 | x-ray diffraction | A, B, C, D | — | 7 (best 0.76) |
| 7QRY | Crystal structure of B30.2 pryspry domain of MID1 | x-ray diffraction | A, B, C, D | — | — |
| O15344 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase midline-1 (O15344) | predicted | A | — | 3 (best 0.40) |
Experiment against prediction
- 7QRY chain A against the predicted model O15344: TM-score 0.97, RMSD 0.98 Å
- 7QRY chain A against the predicted model O15344: TM-score 0.97, RMSD 0.98 Å
- 7QRY chain B against the predicted model O15344: TM-score 0.97, RMSD 1.01 Å
- 7QRY chain B against the predicted model O15344: TM-score 0.97, RMSD 1.01 Å
- 7QRY chain C against the predicted model O15344: TM-score 0.97, RMSD 1.01 Å
- 7QRY chain D against the predicted model O15344: TM-score 0.97, RMSD 1.02 Å
- 7QRY chain D against the predicted model O15344: TM-score 0.97, RMSD 1.02 Å
- 2DQ5 chain A against the predicted model O15344: TM-score 0.71, RMSD 1.74 Å
- 2DQ5 chain A against the predicted model O15344: TM-score 0.71, RMSD 1.74 Å
- 2FFW chain A against the predicted model O15344: TM-score 0.52, RMSD 2.57 Å
Elsewhere
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