MolNFT v1 · #470664 · protein
AlphaFold monomer V2.0 prediction for tryptophan 5-hydroxylase 2 (Q8IWU9)
Q8IWU9: “AlphaFold monomer V2.0 prediction for tryptophan 5-hydroxylase 2 (Q8IWU9)”. 5 pockets (best druggability 0.72). MolNFT v1 #470664 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q8IWU9
- Type
- protein
- Length
- 490 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xaC0be3EEc1211561285218819705F98450F3f3B8
- Molecule
- Tryptophan 5-hydroxylase 2
- UniProt
- Q8IWU9
- Pockets
- 5 · best druggability 0.72
Structure
1 distinct chain · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan 5-hydroxylase 2 | protein | 490 | 44% helix, 16% strand | Q8IWU9 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.72 | 0.99 | 20 | empty |
| 2 | 237 | 0.64 | 0.82 | 26 | empty |
| 3 | 370 | 0.59 | 0.76 | 33 | empty |
| 4 | 138 | 0.49 | 0.79 | 25 | empty |
| 5 | 127 | 0.39 | 0.74 | 17 | empty |
Compared structures
- 4V06 · Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 4V06 · Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7WIY · Cryo-EM structure of human TPH2 tetramer · an experimental structure of the same protein · chain A against B, TM-score 0.68
- 7QRI · Regulatory domain dimer of tryptophan hydroxylase 2 in complex with L-Phe · an experimental structure of the same protein · chain A against A, TM-score 0.17
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IWU9
- Elsewhere: UniProt Q8IWU9 · AlphaFold DB Q8IWU9
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