UniProt Q8IWU9
Tryptophan 5-hydroxylase 2 (Q8IWU9)
Tryptophan 5-hydroxylase 2 (UniProt Q8IWU9), EC 1.14.16.4: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8IWU9
- Protein
- Tryptophan 5-hydroxylase 2
- EC
- 1.14.16.4
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 23 · 3 records with a druggable one
Structures
5 records of Q8IWU9 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4V06 | Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain | x-ray diffraction | A, B | — | — |
| 4V06 | Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain | x-ray diffraction | A, B | — | — |
| 7QRI | Regulatory domain dimer of tryptophan hydroxylase 2 in complex with L-Phe | solution nmr | A, B | PHE | 3 (best 0.66) |
| 7WIY | Cryo-EM structure of human TPH2 tetramer | electron microscopy | B, C, D, A | FE | 15 (best 0.86) |
| Q8IWU9 | AlphaFold monomer V2.0 prediction for tryptophan 5-hydroxylase 2 (Q8IWU9) | predicted | A | — | 5 (best 0.72) |
Ligands
Experiment against prediction
- 4V06 chain B against the predicted model Q8IWU9: TM-score 0.98, RMSD 0.91 Å
- 4V06 chain B against the predicted model Q8IWU9: TM-score 0.98, RMSD 0.91 Å
- 7WIY chain B against the predicted model Q8IWU9: TM-score 0.98, RMSD 0.95 Å
- 7WIY chain D against the predicted model Q8IWU9: TM-score 0.98, RMSD 0.96 Å
- 7WIY chain C against the predicted model Q8IWU9: TM-score 0.98, RMSD 0.96 Å
- 7WIY chain A against the predicted model Q8IWU9: TM-score 0.98, RMSD 0.96 Å
- 4V06 chain A against the predicted model Q8IWU9: TM-score 0.97, RMSD 1.14 Å
- 4V06 chain A against the predicted model Q8IWU9: TM-score 0.97, RMSD 1.14 Å
- 7QRI chain A against the predicted model Q8IWU9: TM-score 0.74, RMSD 2.86 Å
- 7QRI chain B against the predicted model Q8IWU9: TM-score 0.69, RMSD 2.77 Å
Elsewhere
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