MolNFT v1 · #462673 · protein

AlphaFold monomer V2.0 prediction for acyl-coenzyme a thioesterase THEM4 (Q5T1C6)

Q5T1C6: “AlphaFold monomer V2.0 prediction for acyl-coenzyme a thioesterase THEM4 (Q5T1C6)”. 1 pocket (best druggability 0.71). MolNFT v1 #462673 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q5T1C6
Type: protein
Length: 240 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x661f92Fc5950020C7aB410B5F5b9a3f429F49Ae5
Molecule: Acyl-coenzyme a thioesterase THEM4
UniProt: Q5T1C6
Pockets: 1 · best druggability 0.71

Structure

1 distinct chain · 24% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Acyl-coenzyme a thioesterase THEM4	protein	240	24% helix, 30% strand	Q5T1C6

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	672	0.71	0.78	50	empty

Compared structures

4GAH · Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor · an experimental structure of the same protein · chain A against B, TM-score 0.78
4GAH · Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor · an experimental structure of the same protein · chain A against B, TM-score 0.78
4AE8 · Crystal structure of human THEM4 · an experimental structure of the same protein · chain A against A, TM-score 0.69
4AE8 · Crystal structure of human THEM4 · an experimental structure of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5T1C6
Elsewhere: UniProt Q5T1C6 · AlphaFold DB Q5T1C6

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