MolNFT v1 · #454318 · protein
AlphaFold monomer V2.0 prediction for threonine--tRNA ligase (P0A8M3)
P0A8M3: “AlphaFold monomer V2.0 prediction for threonine--tRNA ligase (P0A8M3)”. 6 pockets (best druggability 0.69). MolNFT v1 #454318 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P0A8M3
- Type
- protein
- Length
- 642 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x4Ef77Afb5a3D9F41c95Be3227D1CC986CCb61835
- Molecule
- Threonine--tRNA ligase
- UniProt
- P0A8M3
- Pockets
- 6 · best druggability 0.69
Structure
1 distinct chain · 39% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Threonine--tRNA ligase | protein | 642 | 39% helix, 29% strand | P0A8M3 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 386 | 0.69 | 0.81 | 36 | empty |
| 2 | 175 | 0.50 | 0.78 | 30 | empty |
| 3 | 69 | 0.50 | 0.84 | 19 | empty |
| 4 | 61 | 0.33 | 0.76 | 12 | empty |
| 5 | 71 | 0.28 | 0.72 | 16 | empty |
Compared structures
- 1QF6 · Structure of E. COLI threonyl-tRNA synthetase complexed with its cognate tRNA · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 1QF6 · Structure of E. COLI threonyl-tRNA synthetase complexed with its cognate tRNA · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 4HWR · Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 4HWR · Crystal structure of E. COLI threonyl-tRNA synthetase bound to a novel inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 1EVK · Crystal structure of a truncated form of threonyl-tRNA synthetase with the ligand… · an experimental structure of the same protein · chain A against B, TM-score 0.62
- 1EVK · Crystal structure of a truncated form of threonyl-tRNA synthetase with the ligand… · an experimental structure of the same protein · chain A against B, TM-score 0.62
- 1FYF · Crystal structure of a truncated form of threonyl-tRNA synthetase complexed with a seryl… · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 1FYF · Crystal structure of a truncated form of threonyl-tRNA synthetase complexed with a seryl… · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 1EVL · Crystal structure of a truncated form of threonyl-tRNA synthetase with a threonyl… · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 1EVL · Crystal structure of a truncated form of threonyl-tRNA synthetase with a threonyl… · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 4HWP · Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 4HWP · Crystal structure of E. COLI threonyl-tRNA synthetase bound to a novel inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A8M3
- Elsewhere: UniProt P0A8M3 · AlphaFold DB P0A8M3
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