MolNFT v1 · #447879 · protein

AlphaFold monomer V2.0 prediction for RAS/RAP GTPase-activating protein syngap (Q9QUH6)

Q9QUH6: “AlphaFold monomer V2.0 prediction for RAS/RAP GTPase-activating protein syngap (Q9QUH6)”. 6 pockets (best druggability 0.80). MolNFT v1 #447879 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9QUH6
Type: protein
Length: 1,308 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xA728cC292727e4E14B44D3C9525E1A9da5569A9F
Molecule: RAS/RAP GTPase-activating protein syngap
UniProt: Q9QUH6
Pockets: 6 · best druggability 0.80

Structure

1 distinct chain · 33% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RAS/RAP GTPase-activating protein syngap	protein	1308	33% helix, 8% strand	Q9QUH6

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	765	0.80	0.83	88	empty
2	372	0.61	0.77	42	empty
3	80	0.46	0.82	16	empty
4	57	0.41	0.81	14	empty
5	68	0.40	0.80	16	empty

Compared structures

3BXJ · Crystal Structure of the C2-GAP Fragment of synGAP · an experimental structure of the same protein · chain A against B, TM-score 0.26
3BXJ · Crystal structure of the C2-gap fragment of syngap · an experimental structure of the same protein · chain A against B, TM-score 0.26
8YM2 · Crystal structure of AIDA-1 PTB domain in complex with SynGAP NPxF motif · an experimental structure of the same protein · chain A against B, TM-score 0.01

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9QUH6
Elsewhere: UniProt Q9QUH6 · AlphaFold DB Q9QUH6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.