MolNFT v1 · #432189 · protein

AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 6 (O14544)

O14544: “AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 6 (O14544)”. 3 pockets (best druggability 0.74). MolNFT v1 #432189 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: O14544
Type: protein
Length: 535 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x5ED9733378E46C361470CA3e501C69CDf9e1E73B
Molecule: Suppressor of cytokine signaling 6
UniProt: O14544
Pockets: 3 · best druggability 0.74

Structure

1 distinct chain · 13% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Suppressor of cytokine signaling 6	protein	535	13% helix, 7% strand	O14544

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	887	0.74	0.78	49	empty
2	131	0.42	0.76	26	empty
3	56	0.36	0.79	18	empty

Compared structures

2VIF · Crystal structure of SOCS6 SH2 domain in complex with a C-kit phosphopeptide · an experimental structure of the same protein · chain A against A, TM-score 0.23
2VIF · Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide · an experimental structure of the same protein · chain A against A, TM-score 0.23

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14544
Elsewhere: UniProt O14544 · AlphaFold DB O14544

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