Research workbench
AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 6 (O14544)
Analyse AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 6… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- O14544
- Type
- protein
- Length
- 535 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5ED9733378E46C361470CA3e501C69CDf9e1E73B
- Molecule
- Suppressor of cytokine signaling 6
- UniProt
- O14544
- Pockets
- 3 · best druggability 0.74
Structure
1 distinct chain · 13% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor of cytokine signaling 6 | protein | 535 | 13% helix, 7% strand | O14544 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 887 | 0.74 | 0.78 | 49 | empty |
| 2 | 131 | 0.42 | 0.76 | 26 | empty |
| 3 | 56 | 0.36 | 0.79 | 18 | empty |
Compared structures
- 2VIF · Crystal structure of SOCS6 SH2 domain in complex with a C-kit phosphopeptide · an experimental structure of the same protein · chain A against A, TM-score 0.23
- 2VIF · Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide · an experimental structure of the same protein · chain A against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14544
- Elsewhere: UniProt O14544 · AlphaFold DB O14544
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