MolNFT v1 · #431891 · protein

AlphaFold monomer V2.0 prediction for gamma-1-syntrophin (Q9NSN8)

Q9NSN8: “AlphaFold monomer V2.0 prediction for gamma-1-syntrophin (Q9NSN8)”. 4 pockets (best druggability 0.71). MolNFT v1 #431891 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9NSN8
Type: protein
Length: 517 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x16CCa6E3e9FB6F3BA58AD90F1CA9Ed23Cf6fc7d2
Molecule: Gamma-1-syntrophin
UniProt: Q9NSN8
Pockets: 4 · best druggability 0.71

Structure

1 distinct chain · 23% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gamma-1-syntrophin	protein	517	23% helix, 35% strand	Q9NSN8

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	492	0.71	0.80	51	empty
2	81	0.42	0.79	17	empty
3	125	0.39	0.74	22	empty
4	119	0.39	0.74	20	empty

Compared structures

7QQN · The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3 · an experimental structure of the same protein · chain A against A, TM-score 0.24
7PC8 · The PDZ domain of SNTG1 complexed with the phosphomimetic mutant PDZ- binding motif of… · an experimental structure of the same protein · chain A against B, TM-score 0.22
7PC7 · The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of pten · an experimental structure of the same protein · chain A against A, TM-score 0.22

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NSN8
Elsewhere: UniProt Q9NSN8 · AlphaFold DB Q9NSN8

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