MolNFT v1 · #429029 · protein

AlphaFold monomer V2.0 prediction for transcriptional regulatory protein SIN3 (P22579)

P22579: “AlphaFold monomer V2.0 prediction for transcriptional regulatory protein SIN3 (P22579)”. 20 pockets (best druggability 0.71). MolNFT v1 #429029 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P22579
Type: protein
Length: 1,536 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x465df7875131467ff2726396c9015a010e029Bcc
Molecule: Transcriptional regulatory protein SIN3
UniProt: P22579
Pockets: 20 · best druggability 0.71

Structure

1 distinct chain · 39% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulatory protein SIN3	protein	1536	39% helix, 4% strand	P22579

Pockets

20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	525	0.71	0.80	36	empty
2	519	0.60	0.74	43	empty
3	222	0.59	0.80	30	empty
4	205	0.54	0.78	25	empty
5	78	0.52	0.84	13	empty

Compared structures

8IHT · Rpd3S bound to the nucleosome · an experimental structure of the same protein · chain A against K, TM-score 0.31
6XDJ · Crystal structure analysis of mbp-SIN3 · an experimental structure of the same protein · chain A against A, TM-score 0.10
6XAW · Crystal structure analysis of SIN3-UME6 · an experimental structure of the same protein · chain A against A, TM-score 0.04

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22579
Elsewhere: UniProt P22579 · AlphaFold DB P22579

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