UniProt P22579
Transcriptional regulatory protein SIN3 (P22579)
Transcriptional regulatory protein SIN3 (UniProt P22579): 18 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 204 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P22579
- Protein
- Transcriptional regulatory protein SIN3
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 204 · 17 records with a druggable one
Structures
19 records of P22579 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6XAW | Crystal structure analysis of SIN3-UME6 | x-ray diffraction | A | BR | — |
| 6XDJ | Crystal Structure Analysis of MBP-SIN3 | x-ray diffraction | A, B, C, D | BGC, GLC | 19 (best 0.79) |
| 6XDJ | Crystal structure analysis of mbp-SIN3 | x-ray diffraction | A, B, C, D | BGC, GLC | — |
| 7YI2 | Cryo-EM structure of Rpd3S in loose-state Rpd3S-NCP complex | electron microscopy | A | — | 14 (best 0.82) |
| 7YI3 | Cryo-EM structure of Rpd3S in close-state Rpd3S-NCP complex | electron microscopy | A | — | 15 (best 0.76) |
| 7YI4 | Cryo-EM structure of Rpd3S complex bound to H3K36me3 nucleosome in close state | electron microscopy | A | — | 8 (best 0.78) |
| 7YI5 | Cryo-EM structure of Rpd3S complex bound to H3K36me3 nucleosome in loose state | electron microscopy | A | — | 8 (best 0.80) |
| 8GA8 | Structure of the yeast (HDAC) Rpd3L complex | electron microscopy | A, D | — | 18 (best 0.82) |
| 8HPO | Cryo-EM structure of a SIN3/HDAC complex from budding yeast | electron microscopy | A, B | — | 13 (best 0.86) |
| 8HXX | Cryo-EM structure of the histone deacetylase complex Rpd3S | electron microscopy | K | — | 14 (best 0.83) |
| 8IHT | Rpd3S bound to the nucleosome | electron microscopy | K | — | 9 (best 0.81) |
| 8KC7 | Rpd3S histone deacetylase complex | electron microscopy | B | — | 15 (best 0.79) |
| 8KD3 | Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA | electron microscopy | B | — | 9 (best 0.83) |
| 8KD5 | Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class2 | electron microscopy | B | — | 10 (best 0.81) |
| 8TOF | Rpd3S bound to an H3K36Cme3 modified nucleosome | electron microscopy | A | — | 6 (best 0.81) |
| 8W9C | Cryo-EM structure of the Rpd3S complex from budding yeast | electron microscopy | A | — | 12 (best 0.79) |
| 8W9D | Cryo-EM structure of the Rpd3S-nucleosome complex from budding yeast in State 1 | electron microscopy | A | — | 7 (best 0.83) |
| 8W9F | Cryo-EM structure of the Rpd3S-nucleosome complex from budding yeast in State 3 | electron microscopy | A | — | 7 (best 0.79) |
| P22579 | AlphaFold monomer V2.0 prediction for transcriptional regulatory protein SIN3 (P22579) | predicted | A | — | 20 (best 0.71) |
Ligands
Experiment against prediction
- 6XAW chain A against the predicted model P22579: TM-score 0.93, RMSD 1.25 Å
- 8W9F chain A against the predicted model P22579: TM-score 0.78, RMSD 4.33 Å
- 8W9C chain A against the predicted model P22579: TM-score 0.77, RMSD 4.28 Å
- 8W9D chain A against the predicted model P22579: TM-score 0.76, RMSD 4.42 Å
- 8TOF chain A against the predicted model P22579: TM-score 0.75, RMSD 4.48 Å
- 7YI5 chain A against the predicted model P22579: TM-score 0.75, RMSD 4.34 Å
- 7YI2 chain A against the predicted model P22579: TM-score 0.74, RMSD 4.33 Å
- 7YI4 chain A against the predicted model P22579: TM-score 0.74, RMSD 4.33 Å
- 7YI3 chain A against the predicted model P22579: TM-score 0.74, RMSD 4.33 Å
- 8HXX chain K against the predicted model P22579: TM-score 0.74, RMSD 4.56 Å
Elsewhere
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