MolNFT v1 · #427978 · protein

AlphaFold monomer V2.0 prediction for SH2B adapter protein 1 (Q9NRF2)

Q9NRF2: “AlphaFold monomer V2.0 prediction for SH2B adapter protein 1 (Q9NRF2)”. 2 pockets (best druggability 0.53). MolNFT v1 #427978 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9NRF2
Type: protein
Length: 756 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x7b996410Da79507A3D80841daE0455C84DAf7E51
Molecule: SH2B adapter protein 1
UniProt: Q9NRF2
Pockets: 2 · best druggability 0.53

Structure

1 distinct chain · 15% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SH2B adapter protein 1	protein	756	15% helix, 10% strand	Q9NRF2

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	262	0.53	0.76	26	empty
2	68	0.30	0.73	12	empty

Compared structures

5W3R · SH2B1 SH2 domain · an experimental structure of the same protein · chain A against A, TM-score 0.14
5W3R · SH2B1 SH2 Domain · an experimental structure of the same protein · chain A against A, TM-score 0.14

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NRF2
Elsewhere: UniProt Q9NRF2 · AlphaFold DB Q9NRF2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.